Sliema Wanderers take on St Andrews aiming to make it two wins on the trot.
The Wanderers lost their opening three games but then surprised B’Kara at the weekend.
Floriana take on arch rivals and neighbours Valletta in what is always a hotly contested derby.
In England, out of sorts Manchester United travel to Northampton in their EFL Cup third round tie.
High flying Manchester City visit Swansea.
Tottenham Hotspurs take on Gillingham at White Hart Lane.
In Serie A leaders Napoli visit Genoa.
Juventus are home to Cagliari