Hibernians take on Pembroke in the FA Trophy last 16 tonight.
Premier leaders Hamrun will meet Xaghra United at the Gozo Stadium.
There are two all-Premier ties with Senglea Athletic against Valletta while Santa Lucia take on Mosta.
Already through to the quarter-finals are St Andrews after beating Naxxar on penalties.
Birkirkara are also into the last eight following 4-1 win over Gozo First Division leaders Ghajnsielem.
Gzira recovered from 2 goals down to beat Tarxien Rainbows 4-2 to book their place in the quarter finals.
On Thursday Marsa take on Sirens for the final place in the last eight.